Because the system is compatible with a wide range of reagents, and also allows for an interface with conventional microfluidic channels, many applications are enabled on our system.
NGS Library Prep
Solving the upstream dilemma of sample preparation to deliver on the promise of modern sequencing technology
As the availability and throughput of benchtop sequencers has increased, the cost of sequencing has gone down. What hasn’t changed is the challenge of library preparation for those not prepared to implement workflows on large-scale, liquid handlers.
Technology can perform all sample manipulation steps including enzymatic reactions, incubations, and magnetic bead-based clean ups, offering an automated and fully integrated “sample in, library out” solution. This cartridge-based technology also minimizes user error, cross contamination, and sample swaps.
Our sequencer-agnostic approach also allows for PCR or PCR-free protocols and has been shown to improve library prep reaction efficiency to yield better coverage with less sequencing. Users can create library prep protocols from scratch or edit existing methods with a simple, protocol-based approach.
Miro Technology also facilitates smaller sample inputs with less reagent use, and is a great compliment for low to medium throughput labs who wish to perform complex protocols such as exome capture in a fully automated, self-contained system.
Recording, storage, and retrieval of information on DNA molecules
There are many aspects of Miro Technology that enable synthetic biology applications. The ability to perform multiple enzymatic reactions and handle samples with gentle forces enables the construction and manipulation of long DNA molecules without the shearing forces of manual or automated pipetting.
This is critically important for constructing and maintaining DNA molecules at lengths needed for many synthetic biology applications, be it for gene/chromosome construction and editing or concatenation of molecules for DNA storage.
Our vision is to make the most complex protocols easy and accessible to scientists everywhere.
DNA Extraction From Biological Samples
Achieving the promise of genomic engineering with the efficiency of automation
With the ability to extract nucleic acids (cell-free DNA, nuclear DNA, RNA) from biological samples – cells, whole blood, plasma, or saliva – Miro Technology can automate all processes of the upstream workflow in one device, from extraction through library prep.
End-to-end solution for automated chemical synthesis using digital microfluidics
The advancement of medicinal chemistry programs is limited by the time and resources required to produce high quality drug-candidate molecules. Microscale experimentation offers an innovative solution by enabling efficient access to high quality data without the need for large amounts of often precious materials.
Miro Technology can be utilized not only for microscale chemistry experimentation but also for complex catalytic reactions. This can combine all of the functions necessary for chemical synthesis (reaction setup, workup, and purification) on a cartridge-based platform without the need for liquid handling, creating efficient synthesis of libraries of compounds in an automated fashion within a compact physical footprint.
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